In the latest installment, Aizawa Kousaku (Yamashita Tomohisa) who had left the emergency centre at Shohoku, is working as a neurosurgeon now and busy with operations every day. Shiraishi Megumi (Aragaki Yui) continues to work as a flight doctor at Shohoku which is facing a manpower crunch and is already the staff leader of the flight doctors team. Hiyama Mihoko (Toda Erika) left Shohoku and becomes a gynaecologist at a perinatal medical centre while Saejima Haruka (Higa Manami) is doing well as a flight nurse. Last but not least, Fujikawa Kazuo (Asari Yousuke) is working as an emergency centre doctor specialising in plastic surgery and supports Shiraishi's team as well.
New additions to the cast include Hey! Say! JUMP's Arioka Daiki, Narita Ryo and Araki Yuuko who will be playing new medical interns assigned to the emergency centre for training to become future flight doctors while Baba Fumika will play an aspiring flight nurse. Shiina Kippei will play Tachibana Keisuke, the director of the emergency centre while Ando Masanobu will play Shinkai Hiroki, a neurosurgeon who is fighting with Aizawa for a posting to Toronto University to be a resident doctor in their top-notch neurosurgery department.