Due to the fact that Juri is a new nurse, she has no pearls to her cap. Her colleagues Matsuoka Nana (Shida) who has a sharp tongue and Wada Kinuko (Takanashi) who is unafraid to take the initiative in relationships are also nurses with no pearls. At the top of the department is the matron Tanojima Kokoro (Kimura) who goes by the principle that whatever happens in the hospital should not be revealed to anyone outside. Any nurse who goes against this will have to leave the hospital. Mizuno will play the surgical nurse Iwabuchi Megumi who is a loner in the department and is always at loggerheads with Tanojima.
Yagira Yuya will play the role of an elite doctor Nakano Kotaro who came back from the US. Although he is initially at odds with Juri at the beginning, they develop a close relationship as time goes by. Last but not least, Ishiguro Ken will play the vice director of the hospital and is rumoured to be romantically involved with the nurses including Iwabuchi.